This purified recombinant mouse monoclonal antibodyrecognizes human tuberous sclerosis 2 protein (TSC2).

TSC2, also known as tuberin, is tumor suppressor. It forms a heterodimer with TSC1 to integrate cellular growth and stress signals. The TSC1/TSC2 complex functions in the mTOR pathway by negatively regulating mTOR activity via the small GTP-binding protein Rheb. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not intended for any animal or human therapeuticor diagnostic use.