This purified rabbit anti-cMet polyclonal antibody is specific to human c-Met. Anti-c-Met recognizes the expressed product of the MET gene. Dysregulated c-Met gene expression is observed in a variety of human carcinomas and sarcomas. c-Met also mediates the movement and invasiveness of neoplastic cells and promotes metastasis. Recently, transcription of the c-Met gene was suggested to be a target for regulation by p53. This rabbit anti-cMet polyclonal antibody is validated for use in western blotting, immunohistochemistry, and immunoassay (ELISA).

Antibody Specifications:

• Applications: Validated applications for rabbit anti-cMet polyclonal antibody are western blotting, immunohistochemistry, and immunoassay (ELISA).
• Host Species: The host species of the anti-cMet polyclonal antibody is rabbit.
• Reactivity: Reacts with human c-Met.
• Product Size: Rabbit anti-cMet polyclonal antibody is available in a 100 µg size.

Following its characterization as an activated oncogene (based on its ability to transform normal fibroblasts) Met was characterized as the receptor for hepatocyte growth factor. The c-Met receptor is a disulfide bonded heterodimer consisting of a ~50 kDa extracellular a-chain and a ~145 kDa b-chain with a cytoplasmic tyrosine kinase domain. Both chains are derived from a single precursor protein by proteolytic cleavage. c-Met is expressed in a wide variety of adult and embryonic tissues and transmits biological responses including mitogenesis, morphogenesis and anti-apoptotic activity elicited by HGF. Dysregulated c-Met gene expression is observed in a variety of human carcinomas and sarcomas. c-Met also mediates the movement and invasiveness of neoplastic cells and promotes metastasis. Recently, transcription of the c-Met gene was suggested to be a target for regulation by p53.