This purified oligoclonal recombinant rabbit IgG antibody recognizeshuman junctional adhesion molecule-A (JAM-A).

Specific for JAM-A
JAM-A is a tight junction-associated protein that that co-localizes with the tight junction proteins occludin, ZO-1, and cingulin. JAM-A has been characterized as a member of the immunoglobulin (Ig) superfamily. It is localized at tight junctions in endothelial and epithelial cells, and its sub-cellular distribution is modulated by inflammatory cytokines. JAM-A is also expressed on circulating leukocytes and platelets, as well as in lymphoid tissue. JAM-A appears to be a single copy gene, constitutively expressed on various tissues and cells, that may be involved in cell-cell adhesion through homophilic interactions.

Oligoclonal Antibody Advantages Include:
• Superior lot-to-lot consistency
• Extremely high specificity and sensitivity
• Validated for immunocytochemistry and indirect ELISA

Oligoclonal Antibodies—Exceptional Consistency Helps Save Timeand Money
Life Technologies oligoclonal antibodies are a pool of monoclonalrabbit IgG antibodies targeted against a specific antigen. Oligoclonalantibodies are produced by transfection of mammalian cells with heavyand light chain antibody cDNAs. This provides you with the highestconsistency between lots, eliminating the need to revalidate yourassays for each lot.

Detect Low Levels of Target Protein
Life Technologies oligoclonal antibodies demonstrate much highersensitivity than ordinary antibodies. Proteins expressed in low levels can be detected with high specificity allowing you to use less of yourprecious samples than with ordinary antibodies.

Recombinant Rabbit IgG—Use Like Any Other IgGAntibody
As with traditional IgG antibodies, gel electrophoresis of rabbitoligoclonal antibodies produces a 150 kDa band under non-reducingconditions and 50 kDa and 25 kDa bands under reducing conditions.

For research use only. Not intended for any animal or human therapeuticor diagnostic use.

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