Antibody Specifications:
- Validated in Western Blot and indirect ELISA
- Isotype: Rabbit IgG
- Concentration: 0.5 mg/ml
- Buffer: Phosphate-buffered saline (PBS) with 0.09% sodium azide
Life Technologies' oligoclonal antibodies are a pool of monoclonal rabbit IgG antibodies targeted against a specific antigen. Oligoclonal antibodies are produced by transfection of mammalian cells with heavy and light chain antibody cDNAs. This provides you with the highest consistency between lots, eliminating the need to revalidate your assays for each lot.
Oligoclonal Antibody Advantages Include:
- Superior lot-to-lot consistency
- Extremely high specificity and sensitivity
- Validation by Invitrogen
Alzheimer's Disease (AD) is characterized by the presence in the brain of extracellular plaques and intracellular neurofibrillary tangles (NFTs). The major component of the plaques is Aβ peptide (β-amyloid), a 40 to 43 amino acid peptide cleaved from amyloid precursor protein (APP) by β-secretase (e.g., BACE) and a putative γ secretase. Increased release of the 'longer forms' of Aβ peptide--Aβ42 or Aβ43--which have a greater tendency to aggregate than Aβ40, occurs in individuals expressing certain genetic mutations and/ or expressing certain ApoE alleles, and may involve other, still undiscovered, factors. Many researchers theorize that this increased release of Aβ42/Aβ43 leads to the abnormal deposition of Aβ and the associated neurotoxicity in the brains of affected individuals.
Obtain More Reliable Data
The proprietary recombinant technology employed in the production of Life Technologies' oligoclonal antibodies means you are assured of the greatest degree of reliability. Staining of nonspecific proteins is virtually eliminated while very high sensitivity is achieved
Detect Low Levels of Target Protein
Life Technologies' oligoclonal antibodies demonstrate much higher sensitivity than ordinary antibodies. Proteins expressed in low levels can be detected with high specificity allowing you to use less of your precious samples than with ordinary antibodies.
Recombinant Rabbit IgG-Use Like Any Other IgG Antibody
As with traditional IgG antibodies, gel electrophoresis of rabbit oligoclonal antibodies produces a 150 kDa band under non-reducing conditions and 50 kDa and 25 kDa bands under reducing conditions.
For research use only. Not intended for any animal or human therapeutic or diagnostic use.
Related Link:
Rapidly Locate the Antibody You Need Using the Antibody Search Tool
