This purified P70S6K [pT389] oligoclonal antibody, rabbit (clone B2HCLC) ABfinity™ recombinant recognizes p70 Ribosomal Protein S6 Kinase (p70S6K) [pT389] in human samples. p70 ribosomal protein S6 kinase (p70S6K) is a 70 kDa member of the ribosomal S6 kinase (RSK) family of serine/threonine kinases. It is predominantly localized in the cytoplasm and is essential for pathways by which growth factors trigger cellular proliferation. The P70S6K [pT389] oligoclonal antibody, rabbit (clone B2HCLC) ABfinity™ recombinant is validated for use in western blotting and indirect ELISA.

Antibody Specifications:

• Applications: Validated applications for P70S6K [pT389] oligoclonal antibody, rabbit (clone B2HCLC) ABfinity™ recombinant are western blotting and indirect ELISA.
• Host Species and Isotype: The host species and isotype of the anti- P70S6K [pT389] Oligoclonal antibody is rabbit IgG.
• Clone ID of Oligoclonal Antibody (pAb): The P70S6K [pT389] oligoclonal antibody, rabbit (clone B2HCLC) ABfinity™ recombinant clone is B2HCLC.
• Reactivity: Reacts with human
• Product Size: P70S6K [pT389] oligoclonal antibody, rabbit (clone B2HCLC) ABfinity™ recombinant is available in a 100 µg size.

p70 Ribosomal Protein S6 Kinase (p70S6K) is a 70 kDa member of the ribosomal S6 kinase (RSK) family of serine/threonine kinases. It is predominantly localized in the cytoplasm and is essential for pathways by which growth factors trigger cellular proliferation. Recent studies suggest that p70S6K also regulates cell motility, immune response, and tissue repair. It is activated through the phosphoinositide (PI) 3-kinase-regulated pathway, which is responsible for the generation of inositol lipids, key mediators of intracellular signaling. Activation of p70S6K is linked to the phosphorylation of several threonine and serine residues including T229, T389, T421, S411, and S424. The major rapamycin-sensitive site, threonine 389, is directly phosphorylated in vitro by mTOR.

Oligoclonal Antibodies—Exceptional Consistency Helps Save Time and Money
Our oligoclonal antibodies are a pool of monoclonal rabbit IgG antibodies targeted against a specific antigen. Oligoclonal antibodies are produced by transfection of mammalian cells with heavy and light chain antibody cDNAs. This provides you with the highest consistency between lots, eliminating the need to revalidate your assays for each lot.

Oligoclonal Antibody Advantages Include:
• Superior lot-to-lot consistency
• Extremely high specificity and sensitivity
• Validation by Invitrogen

Obtain More Reliable Data
The proprietary recombinant technology employed in the production of our oligoclonal antibodies means you are assured of the greatest degree of reliability. Staining of nonspecific proteins is virtually eliminated while very high sensitivity is achieved

Detect Low Levels of Target Protein
Our oligoclonal antibodies demonstrate much higher sensitivity than ordinary antibodies. Proteins expressed in low levels can be detected with high specificity allowing you to use less of your precious samples than with ordinary antibodies.

Recombinant Rabbit IgG—Use Like Any Other IgG Antibody
As with traditional IgG antibodies, gel electrophoresis of rabbit oligoclonal antibodies produces a 150 kDa band under non-reducing conditions and 50 kDa and 25 kDa bands under reducing conditions.

For research use only. Not intended for any animal or human therapeutic or diagnostic use.