This is a purified rabbit anti-human Insulin monoclonal antibody (mAb) that can be used in validated applications such as indirect ELISA and immunocytochemistry (ICC).

ABfinity™ antibody characteristics include:

• APPLICATIONS: This Insulin Monoclonal Antibody, ABfinity™ Recombinant has been validated for use in indirect ELISA and immunocytochemistry.
• HOST SPECIES AND ISOTYPE: This is a recombinant rabbit monoclonal IgG against human Insulin.
• CLONE ID OF MONOCLONAL (mAb): The monoclonal antibody clone is 19H4L12.
• REACTIVITY: Along with human Insulin, this monoclonal antibody is predicted to react with monkey, canine, equine, bat, rat, and rabbit.
• PRODUCT SIZE: 100 µg

Specific for Insulin

Insulin is a hormone secreted by the islet cells of the pancreas. It plays a central role in blood glucose homeostasis. It functions by increasing the cell permeability to monosaccharides, amino acids, and fatty acids. It also accelerates glycolysis, pentose phosphate cycle, and glycogen synthesis in liver. Mature insulin is formed after pro-insulin undergoes cleavage into 3 peptides of which the A and B chains are covalently linked via 2 disulphide bonds. Insulin binds to insulin receptor to stimulate glucose uptake.

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