This purified ABfinity™ recombinant rabbit monoclonal antibody recognizes p70S6K in human samples.

ABfinity™ antibody characteristics include:
• Validation in immunocytochemistry, western blot, and indirect ELISA
• Superior lot-to-lot consistency
• Extremely high specificity and sensitivity
• Recombinant rabbit monoclonal antibody
• Specific for p70S6K

The p70 S6 is the ribosomal S6 protein kinase is known for its role in modulating cell-cycle progression (for cell growth and G1 cell cycle progression), cell size, and cell survival. In response to mitogen stimulation, p70 S6 kinase activation up-regulates ribosomal biosynthesis and enhances the translational capacity of the cell. p70 S6 kinase phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5′ oligopyrimidine tract mRNAs. The activity of p70 S6 kinase is controlled by multiple phosphorylation events located within its catalytic, linker, and pseudosubstrate domains. It is phosphorylated and activated by mTOR in mitogenic pathways downstream from phosphoinositide 3-kinase.

Exceptional Consistency Saves You Time and Money
ABfinity™ antibodies are produced by transfection of mammalian cells with heavy and light chain antibody cDNAs. This provides you with the highest consistency between lots, eliminating the need to revalidate your assays for each lot.

High Specificity Means More Reliable Data
The proprietary recombinant technology employed in the production of ABfinity™ antibodies means you are assured of the greatest degree of reliability. Staining of nonspecific proteins is virtually eliminated while very high sensitivity is achieved. Invitrogen has validated this antibody in western blotting.

High Sensitivity Lets You Detect Low Levels of Target Protein
ABfinity™ antibodies demonstrate much higher sensitivity than ordinary antibodies. Proteins expressed in low levels can be detected with high specificity allowing you to use less of your precious samples than with ordinary antibodies.

Recombinant Rabbit IgG – Use Like Any Other IgG Antibody
As with traditional IgG antibodies, gel electrophoresis of ABfinity™ antibodies produces a 150 kDa band under non-reducing conditions and 50 kDa and 25 kDa bands under reducing conditions.

For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.

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