- Applications: Western Blot and indirect ELISA
- Host Species and Isotype: Rabbit IgG
- Species Cross-reactivity: Human
ABfinity™ antibody characteristics include:
- Validation in Western Blotting
- Superior lot-to-lot consistency
- Extremely high specificity and sensitivity
- Recombinant rabbit monoclonal antibody
PDGFR-alpha (Platelet-derived growth factor receptor – alpha polypeptide), belongs to the protein tyrosine kinase family of proteins and PDGF receptor subfamily which consists of two isoforms - alpha and beta. PDGF receptors are cell surface receptor and are mitogens for cells of mesenchymal origin. Activated PDGF receptors lead to control of cell growth, actin reorganization, migration, and differentiation in various signaling pathways. In humans, the gene is located on the q arm of chromosome 4. Mutation of PDGFR-alpha in humans results in cleft palate type malformations. Postnatally, PDGFR-alpha is associated with gliomas and fibrotic disorders of lung, heart and skin (scleroderma).
Exceptional Consistency Saves You Time and Money
ABfinity™ antibodies are produced by transfection of mammalian cells with heavy and light chain antibody cDNAs. This provides you with the highest consistency between lots, eliminating the need to revalidate your assays for each lot.
High Specificity Means More Reliable Data
The proprietary recombinant technology employed in the production of ABfinity™ antibodies means you are assured of the greatest degree of reliability. Staining of nonspecific proteins is virtually eliminated while very high sensitivity is achieved. Invitrogen has validated this antibody in Western blotting.
High Sensitivity Lets You Detect Low Levels of Target Protein
ABfinity™ antibodies demonstrate much higher sensitivity than ordinary antibodies. Proteins expressed in low levels can be detected with high specificity allowing you to use less of your precious samples than with ordinary antibodies.
Recombinant Rabbit IgG—Use Like Any Other IgG Antibody
As with traditional IgG antibodies, gel electrophoresis of ABfinity™ antibodies produces a 150 kDa band under non-reducing conditions and 50 kDa and 25 kDa bands under reducing conditions.
For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.
Learn more about the superior performance of ABfinity™ recombinant monoclonal antibodies
See Invitrogen's full line of ABfinity™ recombinant monoclonal antibodies