ABfinity™ antibody characteristics include:
- Validation in Western blot and indirect ELISA
- Superior lot-to-lot consistency
- Extremely high specificity and sensitivity
- Recombinant rabbit monoclonal antibody
STAT2 (Signal Transducers and Activators of Transcription 2), belongs to the family of STAT (Signal Transducers and Activators of Transcription) proteins. Following activation, these proteins are phosphorylated and translocated to the nucleus where they function as transcription factors (Ref 1). STAT2 is involved in interferon alpha transcription and STAT1 phosphorylation; it is also required for myogenic differentiation. In humans, the gene encoding STAT2 is located on the q arm of the chromosome 12. Splicing variants produce two isoforms for human STAT2.
Exceptional Consistency Saves You Time and Money
ABfinity™ antibodies are produced by transfection of mammalian cells with heavy and light chain antibody cDNAs. This provides you with the highest consistency between lots, eliminating the need to revalidate your assays for each lot.
High Specificity Means More Reliable Data
The proprietary recombinant technology employed in the production of ABfinity™ antibodies means you are assured of the greatest degree of reliability. Staining of nonspecific proteins is virtually eliminated while very high sensitivity is achieved. Invitrogen has validated this antibody in Western blotting.
High Sensitivity Lets You Detect Low Levels of Target Protein
ABfinity™ antibodies demonstrate much higher sensitivity than ordinary antibodies. Proteins expressed in low levels can be detected with high specificity allowing you to use less of your precious samples than with ordinary antibodies.
Recombinant Rabbit IgG—Use Like Any Other IgG Antibody
As with traditional IgG antibodies, gel electrophoresis of ABfinity™ antibodies produces a 150 kDa band under non-reducing conditions and 50 kDa and 25 kDa bands under reducing conditions.
For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.
Related Links:
Learn more about the superior performance of ABfinity™ recombinant monoclonal antibodies
See Invitrogen's full line of ABfinity™ recombinant monoclonal antibodies
Reference:
- Jatiani SS, Baker SJ, Silverman LR, Reddy EP. JAK/STAT Pathways in Cytokine Signaling and Myeloproliferative Disorders: Approaches for Targeted Therapies. Genes Cancer. 2010 Oct;1(10):979-993. PubMed PMID: 21442038
