This purified ABfinity™ recombinant rabbit anti-IGF1R [pY1135/36] monoclonal antibody is specific to Human Insulin Growth Factor-1 Receptor. Insulin growth factor 1 receptor (IGF1R, also known as CD221) belongs to the family of tyrosine receptor kinases. It is involved in activation of various substrates including IGF and neurotensin, regulation of metabolism, cell division, maintenance, and inflammation response. This rabbit anti-IGF1R [pY1135/36] monoclonal antibody is used in western blotting and ELISA applications.

Antibody Specifications:

• Applications: Validated applications for this rabbit anti-IGF1R [pY1135/36] monoclonal antibody are western blotting and ELISA.
• Host Species and Isotype: The host species and isotype of the antibody is rabbit IgG.
• Clone ID of Monoclonal Antibody (mAb): The anti-IGF1R [pY1135/36] monoclonal antibody clone is 15H10L8.
• Reactivity: Reacts with human IGF1R [pY1135/1136].
• Product Size: Rabbit anti-IGF1R [pY1135/36] monoclonal antibody is available in a 100 µg size.

Insulin Growth Factor -1 receptor (IGF1R, also known as CD221) belongs to the family of tyrosine receptor kinases. These kinases are involved in activation of various substrates, including IGF and neurotensin, which are involved in regulation of metabolism, cell division, maintenance, and inflammation response. The protein is a tetramer consisting of two each of α and β subunits of which the α-subunit binds to insulin growth factor-1 with higher affinity than to insulin growth factor-2, resulting in conformational change followed by autophosphorylation of IGF-1R at positions 1134, 1135, and 1136. The activation of IGF-1R in turn results in phosphorylation of substrate protein with sequential activation of RAS, RAF, and mitogen-activated protein kinase isoforms ERKs, p38, and JNK. This results in the transcription of genes that drive proliferation. This antibody recognizes the β-subunit of IGF-1R.