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This purified ABfinity™ recombinant rabbit anti-LRRK2 [pS395] monoclonal antibody is specific to human LRRK2 [pS395]. LRRK2 (Leucine-Rich Repeat Kinase 2), an enzyme commonly known as Dardarin, belongs to the leucine-rich repeat kinase family. The LRRK2 gene is active in brain and other tissues. This rabbit anti-LRRK2 [pS395] monoclonal antibody is used in western blotting and ELISA applications.
• Applications: Validated applications for anti-LRRK2 [pS395] monoclonal antibody are western blotting and ELISA. • Host Species and Isotype: The host species and isotype of the antibody is rabbit IgG. • Clone ID of Monoclonal Antibody (mAb): The anti-LRRK2 [pS395] monoclonal antibody clone is 3H8L19. • Reactivity: Reacts with human LRRK2 [pS395]. • Product Size: Rabbit anti-LRRK2 [pS395] monoclonal antibody is available in a 100 µg size.
LRRK2 (Leucine-Rich Repeat Kinase 2), an enzyme commonly known as Dardarin, belongs to the leucine-rich repeat kinase family. The LRRK2 gene is active in brain and other tissues. A part of the gene provides instructions for synthesis of a protein segment that is rich in leucine. Proteins with leucine-rich regions appear to play a role in activities requiring protein-protein interactions, such as transmitting signals or helping to assemble the cell's structural framework. LRRK2 also possesses a GTPase activity. Phosphorylation at specific sites (e.g. serine 910 and serine 935) determines 14-3-3 binding to LRRK2; 14-3-3 is a regulator of LRRK2-mediated cellular activities. Anomalies in the LRRK2 gene are associated with Parkinson's disease. In humans, the gene encoding LRRK2 is present on the q arm of chromosome 12.
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