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This purified ABfinity™ recombinant rabbit anti-securin monoclonal antibody is specific to human and mouse securin. Rabbit anti-securin monoclonal antibody is also known as Pituitary Tumor-Transforming Gene 1 protein (PTTG1). This rabbit anti-securin monoclonal antibody is used in western blotting, immunofluorescence, and immunocytochemistry applications.
• Applications: Validated applications for this rabbit anti-securin monoclonal antibody are western blotting and immunofluorescence. • Host Species and Isotype: The host species and isotype of the antibody is rabbit IgG. • Clone ID of Monoclonal Antibody (mAb): The rabbit anti-securin monoclonal antibody clone is 19H16L48. • Reactivity: Reacts with human and mouse securin (PTTG-1). • Product Size: Rabbit anti-securin monoclonal antibody is available in a 100 µg size.
Pituitary Tumor-Transforming Gene 1 (PTTG-1) is an oncogene expressed in normal tissues containing proliferating cells and in tumors. PTTG is downstream of the MAP kinase signaling cascade and is phosphorylated at Ser162 by MAPK in vitro. Phosphorylation plays an essential role in PTTG's transactivation function. The PTTG protein contains a DNA-binding domain, and it activates transcription of the c-myc oncogene by binding to the promoter to form a complex. Studies have demonstrated that expression of human PTTG correlates with cell proliferation in a cell cycle dependent manner, and the association of human PTTG with Ku, the regulatory subunit of DNA-dependent protein kinase, is disrupted when a DNA double-strand breaks occurs.
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