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This monoclonal antibody is validated to react with human ERBB2 [pY1248] and has expected reactivity with mouse, rat, rhesus monkey, feline, canine, frog, and chicken ERBB2 [pY1248]. It is validated for use in Western Blots.
erB-2 [pY1248] is encoded by the 2064 gene, also known as NEU; NGL; HER2; TKR1; CD340; HER-2; HER-2⁄neu. ERBB2, a 185 kDa transmembrane protein, is one of four ERBB receptor tyrosine kinases belonging to the Epidermal Growth Factor Receptor (EGFR) family (1). These receptor tyrosine kinases play an important role during cardiovascular and nervous system development (2-3). In both cardiovascular and nervous system development, cell communication and signaling require ERBB family proteins and overexpression of ERBB2 has been found in a variety of human cancer models (2-3). ERBB receptor tyrosine kinases have an extracellular domain involved in ligand binding and receptor homo- or heterodimerization (1). ERBB2 has also been shown to be the preferred receptor for heterodimerization with the other three ERBB proteins (1).
References 1. Birchmeier C (2009) ErbB receptors and the development of the nervous system. Exp Cell Res. 4: 611-18. 2. Muthuswamy SK et al (1999) Controlled dimerization of ErbB receptor provides evidence for differential signaling by homo- and heterodimers. Mol Cell Biol. 10: 6485-57. 3. Pentassuglia L and Sawyer DB (2009) The role of Neuregulin-1beta⁄ErbB signaling in the heart. Exp Cell Res. 4: 627-37.
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