This purified ABfinity™ recombinant rabbit PYK2 [pY402] monoclonal antibody is specific to human PYK2 [pY402]. Protein tyrosine kinase (PYK2) is also known as PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, and RAFTK. This anti-PYK2 [pY402] monoclonal antibody can be used in applications such as western blotting and ELISA.
• Applications: Validated applications for rabbit anti-PYK2 [pY402] monoclonal antibody are western blotting and ELISA.
• Host Species and Isotype: The host species of the antibody is rabbit IgG.
• Clone ID of Monoclonal Antibody (mAb): The rabbit anti-PYK2 monoclonal antibody clone is 17H4L19.
• Reactivity: Reacts with human PYK2.
• Product Size: Rabbit anti-PYK2 [pY402] monoclonal antibody is available in a 100 µg size.
Protein tyrosine kinase (PyK2, also known as PKB, PTK, CAKB, FAK2, CADTK, FADK2, RAFTK, and PTK2B) is expressed in the central nervous system and in cells derived from hematopoietic lineages. In response to stimuli that increase intracellular calcium concentration, PyK2 is rapidly phosphorylated on its tyrosine residues. On activation of the Pyk2 protein, the MAP kinase signaling pathway is activated, causing modulation of ion channel function. Tyrosine phosphorylation of Pyk2 is catalyzed by protein tyrosine phosphatases (PTPs) and tyrosine kinases. PyK2 phosphorylation has important effects on cell growth, differentiation, metabolism, cell cycle regulation, and cytoskeleton function. The PTK focal adhesion family consists of the FAK (focal adhesion kinase) and the RAFT/Pyk2 kinase proteins, also known as CAK-beta and CADTK.
Pyk2 (proline-rich tyrosine kinase 2), is expressed in the central nervous system and cells derived from hematopoietic lineages. The tyrosine residues of Pyk2 are rapidly phosphorylated in response to various stimuli that increase the intracellular calcium concentration. Pyk2 activation results in activation of the MAP kinase signaling pathway, and regulation of ion channels that impact various physiological processes, including cell growth, differentiation, metabolism, cell cycle regulation and cytoskeleton function.