This purified ABfinity™ recombinant rabbit anti-STAT1 [pY701] monoclonal antibody is specific to human STAT1 [pY701]. Based on sequence similarity, reactivity to orangutan, macaque, bovine, swine, sheep, elk, bat, Xenopus, mouse, rat, chicken, and salmon is expected. Rabbit anti-STAT1 [pY701] is specific for pY701 and does not recognize non-phosphorylated STAT1 protein. Rabbit anti-STAT1 [pY701] monoclonal antibody is used in western blotting and immunofluorescence applications.

Antibody Specifications:

• Applications: Validated applications for monoclonal antibody are western blotting and immunofluorescence.
• Host Species and Isotype: The host species and isotype of the antibody is rabbit IgG.
• Clone ID of Monoclonal Antibody (mAb): The rabbit anti-STAT1 [pY701] monoclonal antibody clone is 15H13L67.
• Reactivity: Reacts with human STAT1 [pY701].
• Product Size: Rabbit anti-STAT1 monoclonal antibody is available in a 100 µg size.

STATs (signal transducers and activators of transcription) were originally discovered as two proteins (STAT 1 and 2) involved in IFN-α and IFN-γ signal transduction. Since their initial identification, 5 more STAT proteins have been discovered (STAT 3, 4, 5a, 5b, and 6). STATs undergo tyrosine phosphorylations in response to growth factor or cytokine signaling (in some cases mediated by JAK kinases [Janus Kinases 1, 2, and 3]), resulting in dimerization and translocation of STAT proteins to the nucleus. Phosphorylation at serine residues in certain STATs (STAT 1, 3, 4, and 5) has also been reported, and appears to be required for the maximal activation of these proteins. STAT1 interacts directly with Nipah virus protein W modulating infection. Protein W binds inactive STAT1 in the nucleus preventing activation and downstream signaling.