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This purified ABfinity™ recombinant rabbit anti-EGFR monoclonal antibody is specific to human EGFR and based on sequence identity and similarity, reactivity to mouse, rat, and dog is expected. This rabbit anti-EGFR monoclonal antibody is used in western blotting and immunofluorescence applications.
• Applications: Validated applications for this rabbit anti-EGFR monoclonal antibody are western blotting and immunofluorescence. • Host Species and Isotype: The host species and isotype of the antibody is rabbit IgG. • Clone ID of Monoclonal Antibody (mAb): The monoclonal antibody clone is 30H45L48. • Reactivity: Reacts with human EGFR. • Product Size: Rabbit anti-EGFR monoclonal antibody is available in a 100 µg size.
Epidermal Growth Factor Receptor (EGFR) is a 175 kDa transmembrane glycoprotein which belongs to the tyrosine kinase superfamily. EGFR acts as a receptor for epidermal growth factor (EGF) family. Binding of EGFR to its ligands causes autophosphorylation of tyrosine kinase followed by activation of signal transduction of the pathways connected to cell proliferation and differentiation. Deregulation of EGFR expression has been connected to carcinogenesis and metastasis.
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