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This purified ABfinity™ recombinant rabbit anti-STAT6 [pY641] monoclonal antibody is specific for pY641 and does not recognize non-phosphorylated STAT6. Based on sequence similarity, reactivity to rhesus monkey, orangutan, bovine, canine, mouse, and rat is expected. This rabbit anti-STAT6 [pY641] monoclonal antibody is used in western blotting, ELISA, and immunofluorescence applications.
• Applications: Validated applications for this rabbit anti-STAT6 [pY641] monoclonal antibody are western blotting, ELISA, and immunofluorescence. • Host Species and Isotype: The host species and isotype of the antibody is rabbit IgG. • Clone ID of Monoclonal Antibody (mAb): The monoclonal antibody clone is 46H1L12. • Reactivity: Reacts with human STAT6 [pY641]. • Product Size: Rabbit anti-STAT6 [pY6421] monoclonal antibody is available in a 100 µg size.
STATs (Signal Transducer and Activator of Transcription) are mediators involved in cytokine signaling. These proteins are phosphorylated on conserved tyrosine residues in response to a specific cytokine signal. Phosphorylated STAT proteins move to the nucleus and transcriptionally regulate downstream target genes. STAT6 is activated primarily by IL-3, IL-4 and IL-13 and it is responsible for anti-apoptotic activity of IL-4 through induction of BCL2L1/BCL-X(L). Upon activation, STAT6 is phosphorylated at tyrosine 641 by Janus Kinase (JAK). More than 35 different STAT6 target genes have been identified, many of which are involved in Th2 associated processes.
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