IRF7 ABfinity™ Recombinant Rabbit Monoclonal Antibody is validated to react with human and validated for use in Western Blot. IRF7 is encoded by the 3665 gene, also known as Interferon regulatory factor 7.
IRF-7 is one of nine members of the Interferon Regulatory Factor (IRF) family of transcription factors that facilitate in pathogen defense, autoimmunity, lymphocyte development, cell growth and susceptibility to transformation (1, 3). The IRF7 gene is induced by the Interferon-triggered Jak-STAT pathway and includes two Interferon (IFN) responsive elements, an IRF-binding element (IRFE) in the promoter region and an IFN-stimulated response element in the first intron (2). It has been shown that all elements of IFN responses, whether the systemic production of IFN in innate immunity or the local action of IFN from plasmacytoid dendritic cells in adaptive immunity, are under the control of IRF-7 (1). IRF-7 is similar to IRF-3 in their virus-induced phosphorylation, dimerization, and nuclear transport, but differ in the cell types in which they are expressed and expression levels (4).
1. Honda, K. and Taniguchi, T. (2006) IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 6, 644-658.
2. Ning, S. et al. (2005) Regulation of the Transcriptional Activity of the IRF7 Promoter by a Pathway Independent of Interferon Signaling. The Journal of Bio. Chem. 280, 12262-12270.
3. Taniguchi, T. et al. (2001) IRF Family of Transcription Factors as Regulators of Host Defence. Annu. Rev. Immunol. 19, 623-655.
4. Genin, P. et al (2009) Differential Regulation of Human Interferon A Gene Expression by Interferon Regulatory Factors 3 and 7. Mol. Cell. Biol. 29, 3425-3450.