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This purified rabbit anti-Rab11 monoclonal antibody is specific to human Rab11. Rab11 is encoded by the 8766 gene, also known as RAB11, member RAS oncogene family, Ras-related protein Rab-11A, YL8, and MGC1490. This rabbit anti-Rab11 monoclonal antibody is used in western blotting and immunofluorescence applications.
• Applications: Validated applications for monoclonal antibody are western blotting and immunofluorescence. • Host Species and Isotype: The host species and isotype of the antibody is rabbit IgG. • Clone ID of Monoclonal Antibody (mAb): The monoclonal antibody clone is 3H18L5. • Reactivity: Reacts with human Rab11. • Product Size: Rabbit anti-Rab11 monoclonal antibody is available in a 100 µg size.
Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of α-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via Gβγ trafficking.
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