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This purified ABfinity™ recombinant rabbit anti-c-met [pY1230/34/35] monoclonal antibody is validated to react with human c-met [pY1230/34/35]. Anti-c-met monoclonal antibody does not recognize non-phosphorylated c-Met protein. This rabbit anti-c-Met monoclonal antibody is used in western blotting and ELISA applications.
• Applications: Validated applications for anti-c-met [pY1230/34/35} monoclonal antibody are western blotting and ELISA. • Host Species and Isotype: The host species and isotype of the antibody is rabbit, IgG. • Clone ID of Monoclonal Antibody (mAb): The rabbit anti-c-met [pY1230/34/35] monoclonal antibody clone is 5H27L59. • Reactivity: Reacts specifically with human c-met [pY1230/34/35]. • Product Size: ABfinity™ recombinant rabbit anti-c-met [pY1230/34/35] monoclonal antibody is available in a 10 mini-blot pack.
The c-Met protein is a tyrosine kinase receptor composed of a disulfide-linked heterodimer made of 45 kDa α- and 145 kDa β-subunits found in many tissues. It expresses a trans-membrane receptor-like protein, and is involved in regulating cellular proliferation, motility, morphogenesis, and apoptosis. c-Met encodes a high-affinity receptor for hepatocyte growth factor (HGF), which activates Tyrosine kinase when HGF is bound, auto-phosphorylating several tyrosine residues in its cytoplasmic domain. Additionally, c-Met over-expression has been found in a wide variety of cancer types, particularly lung cancer.
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