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This purified ABfinity™ recombinant rabbit anti-TRAF3 monoclonal antibody is specific to human TRAF3. Based on sequence similarity, reactivity to chimpanzee, rhesus monkey, mouse, rat, swine, canine, bovine, and equine is expected. This rabbit anti-TRAF3 monoclonal antibody can be used in western blotting.
• Applications: The validated application for this rabbit anti-TRAF3 monoclonal antibody is western blotting. • Host Species and Isotype: The host species and isotype of the TRAF3 antibody is rabbit IgG. • Clone ID of Monoclonal Antibody (mAb): The rabbit anti-TRAF3 monoclonal antibody clone is 12H13L59. • Reactivity: Reacts with human TRAF3. • Product Size: Rabbit anti-TRAF3 monoclonal antibody is available in a 100 µg size.
TRAF3, also known as TNF receptor-associated factor 3, is an adapter protein and signal transducer that links multiple members of the tumor necrosis receptor family to different signaling pathways. This is done by association with the receptor cytoplasmic domain and various kinases. It also regulates innate immune system by modulating signaling via Toll-like receptors. Overexpression of TRAF3 does not induce activation of the commonly known TRAF-inducible signaling pathways, NF-κB and JNK. In contrast, it acts as a negative regulator of the NF-κB pathway. Furthermore, TRAF3 is a positive regulator of type I IFN production. These results indicate that TRAF3 is a critical regulator of both innate and adaptive immune responses. In addition to being a major modulator of immune responses, TRAF3 regulates B cell homeostasis in secondary lymphoid organs.
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