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This purified ABfinity™ recombinant rabbit anti-RANBP3 monoclonal antibody is specific to human RAN binding protein 3. Anti-RANBP3 is the product of RANBP3 gene with the gene ID of 8498, and is also known as RAN Binding Protein 3. This rabbit anti-RANBP3 monoclonal antibody is used in western blotting immunocytochemistry, and immunofluorescence applications.
• Applications: Validated applications for this rabbit anti-RANBP3 monoclonal antibody are western blotting and immunofluorescence. • Host Species and Isotype: The host species and isotype of the antibody is rabbit IgG. • Clone ID of Monoclonal Antibody (mAb): The monoclonal antibody clone is B24H15L41. • Reactivity: Reacts with human RAN Binding Protien 3. • Product Size: Rabbit anti-RANBP3 monoclonal antibody is available in a 100 µg size.
Ran Binding Protein 3 (RanBP3) is a member of Ran GTPase binding proteins that is located at the nuclear pore complex (NPC) and plays an essential role in the transport between cytoplasm and nucleus. RANPB3 is expressed as two spliced forms, RanBP3a and RanBP3b, both of which contain two FXFG motifs, characteristic of a subgroup of nucleoporins in addition to nuclear localization signal in the amino-terminal region (amino acid residues 40-57) and a unique acidic carboxyl terminus which is integral to its switch function. RanBP3 binds to importin-α3, and Crm1, a nucleocytoplasmic receptor and plays a key role in mediating Ran signaling function in stabilizing mitotic spindles and regulating nucleocytoplasmic transport. Ran-mediated nuclear transport is regulated at multiple levels via a range of mechanisms including phosphorylation/dephosphorylation events. RanBP3 contains several serine and threonine residues including serine 58. Serine 58 is a RSK kinase site and its phosphorylation is implicated in mediating RanBP3 function and Ran-mediated nuclear transport.
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