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This purified, unconjugated rabbit anti-vinculin monoclonal antibody is specific to human vinculin protein. Rabbit anti-vinculin monoclonal antibody is a recombinant protein corresponding to amino acids 408-591 of P18206. Anti-vinculin monoclonal antibody is used in western blotting, immunohistochemistry, and immunofluorescence applications.
• Applications: Validated applications for this rabbit anti-vinculin monoclonal antibody are western blotting, immunohistochemistry, and immunofluorescence. • Host Species and Isotype: The host species and isotype of the antibody is rabbit IgG. • Clone ID of Monoclonal Antibody (mAb): The monoclonal antibody clone is 42H89L44. • Reactivity: Reacts with human vinculin protein. • Product Size: Rabbit anti-vinculin monoclonal antibody is available in a 100 µg size.
Vinculin (130 kDa) is a ubiquitously expressed cytoskeletal protein that is involved in cell adhesion and migration and plays an important role in embryogenesis. Vinculin is phosphorylated at several residues sites within the tail domain. The vinculin protein consists of a globular head domain connected to an elongated tail region by a proline-rich domain. The head region contains binding sites for two cytoskeletal proteins, α-actinin and talin, as well as a binding site for the tail region of vinculin itself. The tail region contains binding sites for actin and paxillin. Vinculin head controls integrin dynamics whereas the tail controls the functional link between the focal adhesions and the actin cytoskeleton. Cell adhesion and migration require the coordinated formation and release of focal adhesions. During this process, the exchangeable vinculin fraction rises during movement and declines upon maturation.
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