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This purified ABfinity™ recombinant rabbit anti-FAK [pY576] monoclonal antibody is specific to human FAK [pY576] and does not recognize non-phosphorylated FAK protein. Based on sequence similarity, reactivity to chimpanzee, rhesus monkey, macaque, mouse, rat, chicken, Xenopus, and zebrafish is expected. This rabbit anti-FAK [pY576] monoclonal antibody can be used in immunofluorescence.
• Applications: The validated application for this rabbit anti-FAK [pY576] monoclonal antibody is immunofluorescence. • Host Species and Isotype: The host species and isotype of the FAK [pY576] antibody is rabbit IgG. • Clone ID of Monoclonal Antibody (mAb): The rabbit anti-FAK [pY576] monoclonal antibody clone is 2H74L24. • Reactivity: Reacts to human FAK [pY576]. • Product Size: Rabbit anti-FAK [pY576] monoclonal antibody is available in a 100 µg size.
Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling. FAK plays a central role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase transition of the cell cycle. Regulatory mechanisms of FAK include phosphorylation at multiple tyrosine and serine residues. Increased FAK tyrosine phosphorylation occurs upon integrin engagement with fibronectin. The phosphorylation by Src of tyrosines 576 and 577 in the activation loop results in maximal activity of FAK. However, the two sites appear to be differentially regulated.
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