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This rabbit anti-ALK polyclonal antibody is specific to human ALK protein. ALK polyclonal antibody recognizes the expressed product of the ALK gene. Validated applications for ALK polyclonal antibody are immunohistochemistry, Western blotting, ELISA and immunofluorescence.
Applications: validated for immunohistochemistry, Western blotting, ELISA and immunofluorescence Host species and isotype: rabbit IgG Polyclonal Antibody Designation: ZAL4 Reactivity: human ALK Product size: 100 µg pack size
Anaplastic large-cell lymphoma (ALCL), an aggressive subtype of non-Hodgkin's lymphoma, is characterized by CD30+ large neoplastic cells and frequently contains the (2:5) (p23:g35) translocation. The (2:5) translocation results in the production of a chimeric 80 kDa protein, NPM-ALK (Nucleophosmin-Anaplustic lymphoma Kinase) or p80. However, ALK has also been found in cases of large B-cell lymphomas that lack the t (2:5). The ALK+ subset of ALCL have been studied in several recent papers. It has been proposed that ALK+ ALCL is a separate clinicopathologic entity, ALK lymphoma that is distinct from ALK-ALCL. Significantly, it has been reported that ALK lymphoma has a different prognosis than ALKALCL.
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