Unconjugated monoclonal antibody (ascites) specific to human RNA Polymerase II. This antibody is validated for use in Chromatin Immunoprecipitation (ChIP).This antibody has been raised against the largest subunit of RNA polymerase II of wheat germ and interacts with the highly conserved C-terminal domain of this protein containing the repeat YSPTSPS. Pol II subunit B1 is component of the RNA polymerase II (Pol II) complex consisting of 12subunits. Pol II subunit B1 forms the polymerase active center together with the secondlargest subunit. Pol II is the central component of the basal RNA polymerase II transcriptionmachinery. It is composed of mobile elements that move relative to each other. RNA polymerase II (pol II) is an enzyme that by itself can unwind the DNA double helix,synthesize RNA, and proofread the result. When combined with other molecules thatregulate and control the transcription process, Pol II is the key to successful interpretation of an organism's genetic code. This antibody has been raised against the largest subunit of RNA polymerase II of wheat germ and interacts with the highly conserved C-terminal domain of this protein containing the repeat YSPTSPS.