Unconjugated polyclonal antibody specific to human p53. This antibody is validated for use in Chromatin Immunoprecipitation (ChIP), and ELISA. This antibody has been raised in rabbits against human p53, using a C-terminal KLH-conjugated synthetic peptide. The transcription factor p53 is a tumor suppressor that regulates the cellular response to diverse cellular stresses. Upon activation, p53 induces several target genes which leads to cell cycle arrest and DNA repair, or alternatively, to apoptosis. In unstressed cells, p53 is kept inactive by the ubiquitin ligase MDM2 which inhibits the activity and promotes the degradation. Mutations in p53 are involved in a vast majority of human cancers.