Unconjugated polyclonal antibody specific to mouse, human HDAC1. This antibody is validated for use in Chromatin Immunoprecipitation (ChIP), ELISA, Western blotting, Immunoprecipitation (IP) and Immunofluorescence. This antibody has been raised in rabbits against the C-terminal region of human HDAC1, using a KLH-conjugated synthetic peptide. Histone deacetylases (HDAC’s) catalyse the deacetylation of lysine residues on the Nterminal part of the core histones (H2A, H2B, H3 and H4). Acetylation and deacetylation of these highly conserved lysine residues is essential for the epigenetic control of gene expression and plays an important role cell cycle progression and development. Histone deacetylases act via the formation of large multiprotein complexes. HDAC1 (UniProt⁄Swiss-Prot entry Q13547) interacts with several proteins to form protein complexes: Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodelling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to formthe SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2,HMG20B⁄BRAF35, AOF2⁄LSD1, RCOR1⁄CoREST and PHF21A⁄BHC80. TheBHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.?? Associates with the 9-1-1 complex and interacts with HUS1. Found in a complex with DNMT3A and HDAC7. Interacts with BCOR, DAXX, DNMT1, EP300, HCFC1, PCAF, PHB2, MIER1,JMJD2A⁄JHDM3A, MINT, NRIP1, RERE, SETDB1, SUV39H1, TGIF, TGIF2,UHRF1 and UHRF2?? Interacts with the non-histone region of H2AFY. Interacts with HDAC9. Component of a mSin3A corepressor complex that contains SIN3A, SAP130,SUDS3⁄SAP45, ARID4B⁄SAP180, HDAC1 and HDAC2.