This rabbit anti-NMDA NR2A (N-Term) polyclonal antibody is specific to rat NMDA NR2A (N-Term). NMDA NR2A (N-Term) polyclonal antibody recognizes the expressed product of the GRIN2A gene also known as glutamate receptor, ionotropic, N-methyl D-aspartate 2A, N-methyl-D-aspartate receptor channel, subunit epsilon-1, N-methyl-D-aspartate receptor subunit 2A, NMDA receptor subtype 2A, OTTHUMP00000160135, OTTHUMP00000174531. The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. A validated application for rabbit anti-NMDA NR2A (N-Term) polyclonal antibody is Western blotting.

Applications: Validated application for rabbit anti-NMDA NR2A (N-Term) polyclonal antibody is Western blotting.
Host species and isotype: The host species and isotype of the NMDA NR2A (N-Term) polyclonal antibody is rabbit Ig.
Reactivity: Rabbit anti-NMDA NR2A (N-Term) polyclonal antibody detects rat NMDA NR2A (N-Term).
Product size: Rabbit anti-NMDA NR2A (N-Term) polyclonal antibody is available in a 100 µl pack size.

The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.