Polo-Like Kinase 1 [pT210], Phosphospecific Antibody is specific for rat and human. This antibody is validated for use in western blotting. Polo-Like Kinase 1 [pT210], Phosphospecific Antibody recognizes the expressed product of the plk1 gene, also known as polo-like kinase 1, cell cycle regulated protein kinase, polo (Drosophila)-like kinase, polo like kinase, polo-like kinase.

Polo-like kinases are important regulators of cell cycle progression. PLK1 is a highly conserved Ser/Thr kinase that has essential roles in the formation of mitotic bipolar spindles (van Vugt et al., 2004). Deregulated expression of PLK’s is detected in many types of cancer and associated with oncogenesis. It has been proposed that PLK1 function is altered at different stages of mitosis through consecutive phosphorylation events at Ser137 and Thr210.