NMDA Receptor NR2B Subunit [pS1480], Phosphospecific Antibody (SKU# 480022) specific to Rat. This antibody is validated for use in WB. NMDA Receptor NR2B Subunit [pS1480], Phosphospecific Antibody recognizes the expressed product of the GRIN2B gene, also known as glutamate receptor, ionotropic, N-methyl D-aspartate 2B, MGC142178, MGC142180, NMDAR2B, NR2B, hNR3, N-methyl-D-aspartate receptor subunit 2B, glutamate receptor subunit epsilon-2.
The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits (Ishii et al., 1993). It has been shown that phosphorylation of Ser1480 disrupts the interaction of NR2B with the PDZ domains of PSD-95 and SAP102 and decreases surface NR2B expression in neurons.