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GABA Transporter (GAT) 2, Rabbit Polyclonal Antibody (SKU# 480017) specific to Rat. This antibody is validated for use in IHC. GABA Transporter (GAT) 2, Rabbit Polyclonal Antibody recognizes the expressed product of the SLC6A13 gene, also known as solute carrier family 6 (neurotransmitter transporter, GABA), member 13 [Mus musculus], GABA transport protein, GAT-2, GAT2. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl? channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-2 is found in a wide range of neuronal and non-neuronal cells including dendrites and axon terminals as well as epithelial cells and cells forming the pia and arachnoid complex.
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