Tubulin-βIII, Mouse Monoclonal Antibody (SKU# 480011) is specific to Rat. This antibody is validated for use in Western Blotting and IHC. Tubulin-βIII, Mouse Monoclonal Antibody recognizes the expressed product of the Tubb3 gene, also known as MC1R, TUBB4, beta-4, TUBB3.
Tubulin is the major constituent of microtubules, existing as a heterodimer of the a and b subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins. Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy.