This mouse anti-complex I subunit NDUFB8 monoclonal antibody is specific to human, bovine, mouse, and rat complex I subunit. Complex I, or NADH ubiquinone oxidoreductase, is a large protein complex of 950,000 Da molecular weight made up of 45 to 46 different subunits. Validated application for complex I subunit NDUFB8 monoclonal antibody is Western blotting.

Antibody Attributes:

• Applications: Validated application for complex I subunit NDUFB8 monoclonal antibody is Western blotting.
• Host Species and Isotype: The host species and isotype of the complex I subunit NDUFB8 monoclonal antibody is mouse IgG1κ.
• Clone ID of Monoclonal Antibody (mAb): The complex I subunit NDUFB8 monoclonal antibody clone is 20E9DH10C12.
• Reactivity: This complex I subunit NDUFB8 monoclonal antibody detects human, bovine, mouse, and rat complex I subunit.
• Product Size: Complex I Subunit NDUFB8 monoclonal antibody is available in a 100 µg pack size.

Complex I, or NADH ubiquinone oxidoreductase, is a large protein complex of 950,000 Da molecular weight made up of 45 to 46 different subunits. A total of seven of the subunits of the complex are encoded by mitochondrial DNA, while the remainder subunits are nuclear encoded, which are translated in the cytosol and translocated into the organelle for assembly at the inner membrane.

The enzyme complex catalyses electron entry from NADH via a flavin (FMN) and several non-heme iron centers. Complex I is sensitive to a wide range of inhibitors, many of which are pesticides or other common environmental toxins, such as rotenone. Complex I dysfunction is a common cause of genetic OXPHOS defects. Altered functioning of this complex is also thought to contribute to several neurological disorders including Parkinson's disease and schizophrenia. Also, there is evidence of Complex I involvement in diabetes.

Complex I subunit NDUFB8 is encoded by the NDUFB8, also known as RP11-411B6.5, ASHI, CI-ASHI, NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 (8kD, AGGG); NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8 (19kD, ASHI); NADH:ubiquinone oxidoreductase ASHI subunit; OTTHUMP00000020835; OTTHUMP00000059404, NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19 kDa.