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Rabbit Anti-ErbB2 [pY1248]; Polyclonal Antibody specific to Phosphorylated Human ErbB2 [pY1248]. This antibody is validated for use in Western Blot. ErbB2 is encoded by ERB2 gene, also known as ERBB2, HER2, NEU, NGL. ErbB-2 (also known as Her2 or neu) is a 185 kDa transmembrane receptor tyrosine kinase from the EGFR family that acts to regulate a variety of biological responses including cell growth, differentiation, and tissue development. Ligand binding to the extracellular domain, or overexpression of the receptor leads to phosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Overexpression or abnormal activation of ErbB-2 has been found in a variety of tumors including brain, breast, lung and skin cancer. Tyrosine 1248 within the cytoplasmic domain of the receptor is an auto-phosphorylation site that allows binding of Shc and activation of the Ras ® Raf ® ERK1&2 signaling pathway. Catalog number 44904G is same antibody as former catalog number 44904. 44904G contains 50% glycerol, which improves the stability and longevity of this antibody.
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