Binding of scatter factor (SF)⁄hepatocyte growth factor (HGF) to the c-Met receptor tyrosine kinase (RTK) triggers receptor dimerization and phosphorylation on multiple residues within the juxtamembrane, catalytic core and cytoplasmic tail domains, thereby regulating receptor internalization, catalytic activity and multisubstrate docking. Activation of the c-Met⁄HGF receptor results in binding and⁄or phosphorylation of many intracellular signaling proteins including multiple adaptor proteins (e.g., Grb2, Shc, Cbl, Crk, cortactin, paxillin, and GAB1), and a variety of other signal transducers (e.g., PI 3-kinase, FAK, Src, ERK1&2, JNK1&2, PLC-γ, and STAT3).

Format⁄Formulation:
Unconjugated

Application:
WB

Clone:
Polyclonal Catalog number 44892G is same antibody as former catalog number 44892. 44892G contains 50% glycerol, which improves the stability and longevity of this antibody.