c-Met (Hepatocyte Growth Factor receptor) is a ~ 145 kDa receptor tyrosine kinase and is required for cell migration and morphogenic differentiation. c-Met receptor is activated in response to scatter factor (SF)⁄hepatocyte growth factor (HGF) binding. Activated c-Met undergoes dimerization and phosphorylation on multiple residues within the juxtamembrane, catalytic core and cytoplasmic tail domains, thereby regulating receptor internalization, catalytic activity and multisubstrate docking. c-Met contains three tyrosines (Tyr-x-x-x-Tyr-Tyr motif) within the activation loop of the catalytic domain, for which phosphorylation of all three (tyrosines 1230, 1234, and 1235) is required for full activation.

Format:
Unconjugated

Application:
WB

Clone:
Polyclonal

Storage:
FREEZE-20°C

Reference:
Park, M., et al. (2005) Presence of autocrine hepatocyte growth factor-Met signaling and its role in proliferation and migration of SNU-484 gastric cancer cell line. Exp. Mol. Med. 37(3):213-219. Catalog number 44887G is same antibody as former catalog number 44887. 44887G contains 50% glycerol, which improves the stability and longevity of this antibody.