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This rabbit anti-IR [pY1334] polyclonal antibody is specific to human IR [pY1334] and expected to react with mouse and rat (not tested). IR [pY1334] polyclonal antibody recognizes the expressed product of the INSR gene. Insulin Receptor (IR) and Insulin-like Growth Factor Receptor (IGF-1R) are transmembrane tyrosine kinase receptors that play critical roles in development, cell growth and metabolism. Validated application for IR [pY1334] polyclonal antibody is Western blotting.
Applications: validated for Western blotting Host species and isotype: rabbit IgG Reactivity: human, (mouse, rat) IR [pY1334] Product size: 10 blots pack size
Insulin Receptor (IR) and Insulin-like Growth Factor Receptor (IGF-1R) are transmembrane tyrosine kinase receptors that play critical roles in development, cell growth and metabolism. Both receptors are composed of α subunits which contain ligand binding sites, and β subunits which are hormone stimulated, tyrosine-specific protein kinases. The β subunits contain several autophosphorylation sites located in three major domains: the juxtamembrane domain, the activation domain, and the carboxyl domain. Activation of the tyrosine kinase activity of IR results in immediate autophosphorylation of six tyrosine residues followed by the serine sites in the β subunit (98 kDa) and tyrosine and serine phosphorylation of the intracellular substrates of the receptor. Tyrosine autophosphorylation within the activation loop is correlated with full activation of the receptor. The C terminus of the β-subunit of the Insulin Receptor contains two tyrosine residues in the distal region (tyrosine 1328 and tyrosine 1334) that are phosphorylated in response to insulin. Phosphorylation of tyrosines 1328 and 1334 is required for the insulin-stimulated tyrosine dephosphorylation of pp125FAK and play an inhibitory role of insulin-induced mitogenic signaling.
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