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This purified rabbit IR/IGF1R [pYpY 1162/1163] polyclonal antibody is specific for the human, mouse, and rat IGF1R [pYpY 1162/1163]. The IR and IGF-1R are heterotetrameric proteins consisting of two ligand-binding α subunits and two β subunits that each contains a tyrosine kinase domain. IR/IGF1R Polyclonal Antibody can be used in applications such as western blotting and immunohistochemistry.
• Applications: Validated applications for this rabbit IR/IGF1R polyclonal antibody are western blotting and immunohistochemistry. • Host Species: The host species of this polyclonal antibody is rabbit. • Reactivity: Detects human IR/IGF1R. Mouse and rat have not been tested but are expected to react due to 100% sequence homology. • Product Size: IR/IGF1R polyclonal antibody is available in a 10 mini-blot pack size.
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The IR and IGF-1R are heterotetrameric proteins consisting of two ligand-binding α subunits and two β subunits that each contains a tyrosine kinase domain. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of the receptor and activation of the intrinsic tyrosine kinase activity, leading to tyrosine phosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor.
The catalytic loops within the tyrosine kinase domains of the IR/IGF1R contain a three tyrosine motif corresponding to tyrosines 1158, 1162 and 1163 (for the IR) and 1131, 1135 and 1136 (for the IGF1R). It is generally believed that autophosphorylation within the activation loop proceeds in a processive manner initiating at the second tyrosine (1162 or 1135), followed by phosphorylation at the first tyrosine (1158 or 1131), then the last (1163 or 1136), upon which the IR or IGF1R becomes fully active.
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