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The purified rabbit EGFR [pY1068] polyclonal antibody is specific to human and rat EGFR [pY1068]. EGFR polyclonal antibody, also known as ErbB-1, is a transmembrane tyrosine kinase that regulates a variety of biological responses ranging from mitogenesis to stress signaling.
• Applications: The validated application for EGFR [pY1068] polyclonal antibody is western blotting. • Host Species: The host species of the EGFR [pY1068] antibody is rabbit. • Reactivity: Detects human EGFR. Mouse and rat EGFR have not been tested but are expected to react. • Product Size: EGFR [pY1068] polyclonal antibody is available in a 10 blot pack.
Epidermal growth factor receptor (EGFR, a 185 kDa glycoprotein), also known as ErbB-1, is a transmembrane tyrosine kinase that regulates a variety of biological responses ranging from mitogenesis to stress signaling. The EGFR consists of a large extracellular domain, a single transmembrane domain, and a cytoplasmic domain that exhibits kinase activity. Upon binding of EGF to the extracellular domain, the receptor undergoes dimerization and becomes phosphorylated on several tyrosine residues within the cytoplasmic domain. These events result in EGFR activation and increased tyrosine kinase activity toward a variety of intracellular substrates. Tyrosine 1068, within the cytoplasmic domain of the receptor, is a major autophosphorylation site that allows binding of Grb2 and activation of the Ras –> Raf –> ERK1&2 signaling pathway. Reactivity is to human EGFR.
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