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The TaqMan® OpenArray® PGx Panel (derived from the PharmaADME Core Marker Set) is an efficient, easy-to-use OpenArray® plate for pharmacogenomics applications. The assays were developed to detect polymorphisms in genes encoding drug metabolism enzymes and associated transport proteins. The panel contains 158 assays.
Each TaqMan® Drug Metabolism genotyping assay in the panel contains two allele-specific probes and a primer pair to detect the specific SNP target. Both the probes and primers uniquely align within the genome, enabling the TaqMan® genotyping technology to provide superior specificity. It is this specificity that allows these assays to detect targets residing in highly homologous gene families that may include pseudogenes. TaqMan® Drug Metabolism genotyping assays were developed using a high level of bioinformatics and wet-lab stringency. All assays have passed performance tests involving 180 unique DNA samples from four different populations.
The plate is pre-formatted and inventoried, cost-effective, convenient, and easy-to-use, without the need for expensive robotics. Results are reproducible and consistent across samples, studies, and labs—for the same data quality from card-to-card and lot-to-lot, even with different operators.
For fast delivery, all assays in this collection have been manufactured and placed into inventory and are ready to ship at ambient temperature.
This panel is intended for use with the QuantStudio™ 12K Flex Real-time PCR system, which offers high throughput profiling of 5,184 samples per work day, generating 43,000 expression profiles without expensive robotics while saving precious sample and lowering reagent costs.
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