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This rabbit anti-IKK-alpha [pSpS176/180] polyclonal antibody is specific to human IKK-alpha [pSpS176/180] and expected to react with mouse (not tested). IKK-alpha [pSpS176/180] polyclonal antibody recognizes the expressed product of the CHUK gene. IκB Kinase-α (IKKα) is an 85 kDa cytoplasmic serine kinase that forms a complex (IKK complex) with a second serine kinase, IKKβ, and a structural/regulatory component, IKKγ (also known as NEMO or IKKAP). The IKK complex plays a central role in the regulation of transcription mediated by the NFκB transcription factor. Validated application for IKK-alpha [pSpS176/180] polyclonal antibody is Western blotting.
Applications: validated for Western blotting Host species and isotype: rabbit IgG Reactivity: human (mouse) IKK-alpha [pSpS176/180] Product size: 10 blots pack size.
IκB Kinase-α (IKKα) is an 85 kDa cytoplasmic serine kinase that forms a complex (IKK complex) with a second serine kinase, IKKβ, and a structural/regulatory component, IKKγ (also known as NEMO or IKKAP). The IKK complex plays a central role in the regulation of transcription mediated by the NFκB transcription factor. In the absence of a stimulus, NFκB is sequestered in the cytoplasm in an inactive form through its binding to inhibitory proteins, primarily Inhibitor of NFκB (IκB). In response to a variety of stimuli (e.g., proinflammatory cytokines, tumor necrosis factor, and interleukin-1β) the IKK complex is activated through phosphorylation of IKKα and IKKβ by members of the MAPK kinase kinase family, including NFκB-Induced Kinase (NIK), TGF-β-Activated Kinase 1 (TAK1), and MEKK1. Activation of the IKK complex may also occur stepwise through stimulus-induced phosphorylation of ΙΚΚα which then phosphorylates and activates IKKβ. The now activated IKK complex phosphorylates IκB leading to its subsequent ubiquitination and degradation by the proteasome. The free NFκB translocates to the nucleus and stimulates ranscription of NFκBresponsive genes. IKKα activation is dependent on phosphorylation of serine 176 and serine 180 residues within the kinase activation loop.
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