This purified Rabbit Anti-ERK 1/2 [pTpY185/187] Polyclonal Antibody is specific to human, mouse, and rat ERK 1/2 [pT185/pY187]. Anti-ERK1/2 [pT185/pY187] antibody recognizes the product of the MAPK3 gene. ERK (extracellular signal-regulated kinase), also known as MAPK (mitogen-activated protein kinase) has two closely related isoforms of 44 kDa and 42 kDa. Rabbit anti ERK 1/2 [pTpY185/187] Polyclonal Antibody is validated for use in immunohistochemistry and western blotting.

Antibody Specifications:

• Applications: Validated applications for Rabbit Anti-ERK 1/2 [pTpY185/187] Polyclonal Antibody are western blotting and immunohistochemistry.
• Host Species: The host species of the ERK 1/2 [pTpY185/187] Polyclonal Antibody is rabbit.
• Reactivity: Detects human, mouse, and rat ERK 1/2 [pTpY185/187].
• Product Size: ERK 1/2 [pTpY185/187] Polyclonal Antibody is available in a 100 µL pack size.

ERK (extracellular signal-regulated kinase), also known as MAPK (mitogen-activated protein kinase), has two closely related isoforms of 44 kDa and 42 kDa. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines and bioactive peptides, Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth, differentiation and the cytoskeleton. ERK1 and ERK2 are fully activated by phosphorylation within a Thr-Glu-Tyr-motif of the activation loop on both a threonine and a tyrosine residue by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of the ERK 1 & 2 enzymes.