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This purified rabbit anti-ERK1/2 polyclonal antibody is specific to human, mouse, rat and bovine ERK 1+2. Anti-ERK1+2 polyclonal antibody recognizes the expressed product of the MAPK3 gene. ERK (extracellular signal regulated kinase), also known as MAPK (mitogen-activated protein kinase) has two closely related isoforms designated ERK1 and ERK2 (44 kDa and 42 kDa, respectively).This antibody is validated for use in western blotting.
• Applications: Validated application for Rabbit anti-ERK1/2 polyclonal antibody is western blotting. • Host Species: The host species of the anti-ERK1/2 polyclonal antibody is rabbit. • Reactivity: Reacts with human, mouse, rat and bovine ERK1/2 • Product Size: Rabbit anti-ERK1/2 polyclonal antibody is available in a 10 blot pack.
ERK (extracellular signal regulated kinase), also known as MAPK (mitogen-activated protein kinase) has two closely related isoforms designated ERK1 and ERK2 (44 kDa and 42 kDa, respectively). These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth and differentiation as well as the cytoskeleton. ERK1 and ERK2 are phosphorylated within the activation loop on both a threonine and a tyrosine residue (within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of ERK1 and 2.
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