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The purified rabbit AKT/PKB [pS473] monoclonal antibody is specific to human, mouse, and rat Akt [pS473]. AKT/PKB plays an important role in regulation of metabolism, cell survival and growth. Western blotting and immunocytochemistry are the validated applications for AKT/PKB [pS473] monoclonal antibody. Anti-Akt [pS473] recognizes the expressed product of the AKT1 gene.
• Applications: Validated applications for this AKT/PKB [pS473] monoclonal antibody are western blotting and immunocytochemistry. • Host Species and Isotype: The host species of the AKT/PKB [pS473] antibody is rabbit and the isotype is IgG. • Clone ID of Monoclonal Antibody (mAb): The monoclonal antibody clone is 14-6. • Reactivity: Detects Human and mouse AKT1, 2, and 3. • Product Size: AKT/PKB [pS473] monoclonal antibody is available in a 10 mini-blot pack.
Akt, also known as Protein Kinase B (PKB) or RAC-α, is a 65 kDa serine/threonine kinase that plays an important role in diverse biological responses such as regulation of metabolism, cell survival, and growth by phosphorylating many proteins including GSK-3β, caspase 9, BAD and the Forkhead Transcription Factor. Akt is activated by PI3K, which in turn can interact with proteins such as FAK (when FAK is phosphorylated at tyrosine 397) thereby linking activation to the cytoskeleton. Akt is phosphorylated on threonine 308 by PDK1 and on serine 473 by PDK2. Phosphorylation at serine 473 is required for full activation of Akt.
The antibody was produced against a chemically synthesized phosphopeptide derived from the region of human Akt that contains serine 473. The sequence is conserved among multiple species including mouse and rat across the three isoforms, Akt1, Akt2 and Akt3.
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