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This purified rabbit anti-GSK3β[pY216]/GSK3-α[pY279] polyclonal antibody is specific to human, mouse, and rat GSK-3α[pY279]/β[pY216]. Rabbit anti-GSK3β[pY216]/GSK3-α[pY279] polyclonal antibody is used in western blotting and ELISA applications.
• Applications: Validated applications for rabbit anti-GSK3β[pY216]/GSK3-α[pY279] polyclonal antibody are western blotting and ELISA. • Host Species: The host species of the antibody is rabbit. • Also Known As: Rabbit anti-GSK3α/GSK3β is also known as GSK-3, GSK3-beta, and GSK3-alpha. • Reactivity: Reacts with human, mouse, and rat GSK3-alpha/beta. • Product Size: Rabbit anti-GSK3β[pY216]/α[pY279] polyclonal antibody is available in a 10 mini-blot pack.
Glycogen synthase kinase-3 (GSK-3) is a non-receptor protein serine/threonine kinase and a critical modulator of cell fate, neuronal plasticity, and tumorigenesis. GSK-3 consists of two isoforms, α (51 kDa) and β (47 kDa). Phosphorylation of the kinase activation loop on GSK-3α tyrosine 279 (tyrosine 216 for GSK-3β) by focal adhesion kinase (FAK) or proline-rich/Ca2+-activated tyrosine kinase (Pyk2) activates GSK-3α/β, inhibiting glycogen synthesis and thereby inducing apoptosis. GSK-3β also hyper-phosphorylates the microtubule binding protein Tau, leading to paired helical formation, a marker in the pathogenesis of Alzheimer's disease.
Rabbit anti-GSK3α[pY279]/β[pY216] polyclonal antibody has been purified from rabbit serum by epitope-specific affinity chromatography. The antibody has been negatively pre-adsorbed using a non-phosphopeptide corresponding to the site of phosphorylation to remove antibody that is reactive with non-phosphorylated GSK-3α/β. The final product is generated by affinity chromatography using a GSK-3α/β-derived peptide that is phosphorylated at tyrosine 279/216.
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