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This rabbit anti-RB [pT821] polyclonal antibody is specific to human, (mouse, rat) RB [pT821]. RB [pT821] polyclonal antibody recognizes the expressed product of the RB1 gene. Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F-1, PU.1, ATF-2, UBF, Elf-1, and c-Abl. Validated application for RB [pT821] polyclonal antibody is Western blotting.
• Applications: Validated application for this RB [pT821] polyclonal antibody is Western blotting.
• Host Species and Isotype: The host species and isotype of the RB [pT821] polyclonal antibody is rabbit IgG.
• Reactivity: RB [pT821] polyclonal antibody detects human RB [pT821].
• Product Size: RB [pT821] polyclonal antibody is available in 10 blots pack size.
Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F-1, PU.1, ATF-2, UBF, Elf-1 and c-Abl. This ability to alter transcription is regulated by phosphorylation catalyzed by the cyclin-dependent protein kinases (cdks). Rb contains at least 16 consensus sequences for cdk phosphorylation, but the significance of all of these sites is unclear. Rb threonine-821 phosphorylation (catalyzed by cdk2) disrupts interaction with proteins containing the sequence LxCxE. Phosphorylation of this site (in addition to serines 780, 807, and 811) also disrupts binding to E2F.
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