This rabbit anti-CD117 (c-Kit) [pY703] polyclonal antibody is specific to human CD117 (c-Kit) [pY703]. This CD117 polyclonal antibody is also expected to react with mouse, rat, cow and dog (92% homologous), or chicken (69%), but has not been tested. CD117 (c-Kit) [pY703] polyclonal antibody recognizes the expressed product of the KIT gene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. A validated application for CD117 (c-Kit) [pY703] polyclonal antibody is Western blotting.

Applications: Validated application for CD117 (c-Kit) [pY703] polyclonal antibody is Western blotting.
Host species and isotype: The host species and isotype of the CD117 (c-Kit) [pY703] polyclonal antibody is rabbit IgG.
Reactivity: CD117 (c-Kit) [pY703] polyclonal antibody detects human (mouse, rat, cow, dog or chicken) CD117 (c-Kit) [pY703].
Product size: CD117 (c-Kit) [pY703] polyclonal antibody is available in 10 blots pack size

c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras —> Raf —> ERK1&2 signaling pathway.