Copy and paste this HTML to embed a link in your website
Paste link in email or IM
Mitogen-Activated Protein Kinase Kinase 4 (MEK4 or MKK4) is a 42 kDa member of a tyrosine⁄threonine protein kinase family that activates the c-Jun NH2-terminal kinases (JNK), which is part of the inflammation⁄stress signaling pathway. The mutation of the MEK4 gene in some carcinomas indicates that it may also have a role as a tumor suppressor. Phosphorylation of MEK4 by MEKK1 on serine 257 and threonine 261 in the catalytic domain activates the protein and enables MEK4 to phosphorylate JNK.
Rabbit (polyclonal) Anti-MEK4 [pSpT257⁄261] Phosphospecific Antibody, Unconjugated is reactive to human MEK4 and is validated in Western Blot. Mouse and frog (100% homologous) MEK4 have not been tested, but are expected to react. Mek4 is also known as MAP2K4, mitogen-activated protein kinase kinase 4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SEK1, SERK1, JNK activating kinase 1; JNK-activated kinase 1; MAP kinase kinase 4; MAPK⁄ERK kinase 4; SAPK⁄ERK kinase 1; c-Jun N-terminal kinase kinase 1. Catalog number 44474G is the same antibody as former catalog number 44474. 44474G contains 50% glycerol, which improves the stability and longevity of this antibody.
If you continue without changing your settings, we'll assume that you are happy to receive all cookies on Life Technologies websites. However, you can change your cookie settings at any time at the bottom of this page.
To access this page, please close your session and log into the PunchOut session again. You will need to provide an email address on the sign-in page.Please note if you are a punchout to supply center customer, and are viewing this message, your procurement system does not provide the required information to access this tool. Please contact your procurement system administrator for further instructions.