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Signal transducer and activator of transcription proteins (STATs) are mediators involved in cytokine signaling. In response to a specific cytokine signal, STAT proteins are phosphorylated on conserved tyrosine residues. Phosphorylated STAT proteins dimerize via their Src homology SH2 domains and move to the nucleus. The STAT dimers bind to specific DNA elements resulting in transcriptional regulation of downstream target genes. STAT6 is activated primarily by IL-4 and IL-13. Upon activation, STAT6 is phosphorylated at tyrosine 641 by Janus Kinase (JAK). Phosphorylated STAT6 forms head-to-tail heterodimers and translocates to the nucleus where it participates in transcriptional control.
Isotype: Mouse IgG1
Immunogen: Phosphopeptide containing amino acid sequence GRG[pY]VPA, conjugated to KLH.
Specificity: This antibody specifically recognizes activated STAT6 phosphorylated at tyrosine 641 (100 kDa). The antibody does not cross-react with the non-phosphorylated form of STAT6 or with unrelated phosphorylation sites.
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